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Issue:
Experimental Study on the Sedation of Shukemian Capsule
Author(s):
JIA Lili
,
FENG Mali
,
WU Yupeng
,
NIU Yanyan
,
LI Peiyi
Pages:
11
-
12
Year:
2003
Issue:
2
Journal:
JOURNAL OF SHANXI COLLEGE OF TRADITIONAL CHINESE MEDICINE
Keyword:
疏可眠胶囊
;
镇择
;
抗惊厥
;
Abstract:
目的:观察疏可眠胶囊对小鼠的镇静作用.方法:采用旷野活动法观察疏可眠胶囊不同给药剂量、给药时间对小鼠自主活动的量效、时效作用;对士的宁诱发惊厥小鼠的作用.结果:连续给药7d,疏可眠低中剂量(1 g@kg-1、2 g@kg-1)均能显著减少小鼠的自主活动;疏可眠高剂量(3 g@kg-1)给药后1 h~2h自主活动显著减少;给药后2 h,呈现量效关系,随着剂量增加小鼠自主活动减少.各剂量组均可延长士的宁诱发小鼠惊厥出现的时间及死亡时间.结论:疏可眠胶囊具有减少小鼠自主活动和抗惊厥作用.
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