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Status analysis of clinical application and acute renal injury monitoring of vancomycin in some areas of China
Author(s): ZHOU Ying, LIU Xiao, MA Ling-yun, CHEN Chao-yang, YANG Ting, ZHANG Xiang-lin, CHEN Wen-qian, CUI Yi-min, YANG Li, Department of Pharmacy, Peking University First Hospital, Department of Pharmacy, China-Japan Friendship Hospital, Department of Nephrology, Peking University First Hospital
Pages: 1298-
1302
Year: 2019
Issue:
12
Journal: The Chinese Journal of Clinical Pharmacology
Keyword: vancomycin; therapeutic drug monitoring; serum creatinine test;
Abstract: Objective To make a investigation in parts of China about vancomycin using and vancomycin induced acute kidney injury.Methods Using questionnaire survey and literature research to collect the data of vancomycin usage in hospitals,therapeutic drug monitoring(TDM) situation and serum creatinine(SCr) monitoring,then use Excel to analyze data.Results Vancomycin drug investigation include 103 medical institutions from Beijing,Chengdu,Guangzhou,Hangzhou,Shanghai,Tianjin,Zhengzhou and Shenyang.The proportion of vancomycin in clinical use was 31.4%-94.4%,and there was an upward trend in some areas.The investigation of vancomycin TDM include 214 medical institutions from 29 provinces.Most hospitals,especially tertiary hospitals,conducted vancomycin TDM.The reference searching study of vancomycin SCr monitoring contains 37 references in English and Chinese.Most of them detection SCr before and after drug using,but almost at different time.Conclusion Vancomycin TDM monitoring method has been relatively mature in China.Part of the hospitals has been used to monitor the patient’s SCr,but the monitoring time,monitoring objects are still not normative.Therefore, normative vancomycin guidelines and useing software or information systems to achieve mandatory implementation of SCr and TDM are reasonable ways.
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