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Influence of Jiajianxiayuxuetang on Expressing the Scavenger Receptor of Humen Mesangial Cell
Author(s): 
Pages: 67-70
Year: Issue:  2
Journal: CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN NEPHROLOGY

Keyword:  加减下瘀血汤人肾小球系膜细胞清道夫受体;
Abstract: 目的:探讨加减下瘀血汤对人肾小球系膜细胞(HMC)表面清道夫受体A(SR-A)表达的影响.方法:通过采用体外培养HMC,在佛波酯(PMA)刺激SR-A上调后,用加减下瘀血汤含药血清对其进行干预,观察加减下瘀血汤对HMC表面SR-A mRNA表达水平及SR-A与配体结合能力的影响.结果:(1)体外培养的HMC在PMA的刺激下SR-AmRNA水平明显增高,摄取乙酰化低密度脂蛋白(AC-LDL)能力增强,其作用随药物浓度增加而增强(P<0.05);(2)中、高浓度的加减下瘀血汤含药血清能下调PMA诱导SR-AmRNA水平的上调,低浓度含药血清作用不明显.且该作用随着药物浓度的增加、作用时间的延长而增强(P<0.05).结论:加减下瘀血汤治疗肾病的机理之一,可能是通过抑制病理状态下HMC表面SR-A的高表达.
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