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Mycophenkplte Mofetil in the Treatment of Primary Refractory Nephrotic Syndrome and Type Ⅳ Lupus Nephritis
Author(s): 
Pages: 86-88
Year: Issue:  2
Journal: CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN NEPHROLOGY

Keyword:  难治性肾病综合征弥漫增殖性狼疮肾炎霉酚酸酯;
Abstract: 目的:观察霉酚酸酯(MMF)在治疗原发性难治性肾病综合征与弥漫增殖性狼疮性肾炎的疗效比较.方法:观察难治性肾病综合征15例及同期弥漫增殖性狼疮性肾炎(ⅣLN)18例.以强的松0.4 mg~0.7ng@kg-1@d-1联合MMF1.0~1.52次/d,3~6个月后减半维持1年,定期随访.结果:以强的松联合MMF治疗,对ⅣLN疗效良好,完全缓解率达100%,其中3个月内缓解12例,6个月内缓解17例.而在原发性肾病综合征中,对MCD和MsPGN疗效良好,与ⅣLN相似,在MN中2例完全缓解,3例仅部分缓解,2例无效.而后者均在6~9个月间,对FSGS和MPGN仅1例在9个月后部分缓解,2例无效.结论:MMF对MCD和MsPGN效果良好,对MN显示部分疗效,对FSGS和MPGN的疗效较差.总体上MMF对难治性肾病综合征的疗效逊于ⅣLN.
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