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Issue:
Study of angiogenesis in bone marrow of patients with acute leukemia
Author(s):
ZHANG Jinqiao
,
WANG Jinzuo
,
LI Yingmin
,
LV Hongyan
,
ZHANG Min
Pages:
29
-
30
Year:
2003
Issue:
1
Journal:
JOURNAL OF CLINICAL INTERNAL MEDICINE
Keyword:
血管生成
;
白血病
;
骨髓检查
;
活组织检查
;
Abstract:
目的研究血管生成在急性白血病发病、预后中的作用.方法应用免疫组化法检测30例初治急性白血病患者的骨髓活检组织治疗前后微血管密度(MVD)及血管内皮生长因子(VEGF)的变化.结果初治急性白血病患者骨髓病理组织中的MVD和VEGF阳性率明显高于正常对照组;骨髓完全缓解后其MVD及VEGF阳性率明显下降,与正常对照组无显著性差异;治疗后未完全缓解组的MVD及VEGF阳性率较治疗前无显著性下降.结论急性白血病骨髓中存在血管生成,可能与急性白血病的预后有关.
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