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The clinical significance of GADA in distinguishing T2DM and diagnosing LADA in early stage
Author(s): MENG Dong, CHEN Ying, LIU Demin
Pages: 78-
79,84
Year: 2003
Issue:
1
Journal: JOURNAL OF TIANJIN MEDICAL UNIVERSITY
Keyword: 谷氨酸脱羧酶抗体; 2型糖尿病; 胰岛细胞抗体;
Abstract: 目的:探讨2型糖尿病(T2DM)患者检测谷氨酸脱羧酶抗体(GADA)的临床意义.方法:对70例GADA阴性的T2DM患者,45例GADA阳性T2DM患者测定其ICA和体重指数,并于空腹和口服葡萄糖120 min时分别取静脉血,测定其C-肽和血糖的水平.结果:GADA阳性T2DM组血C-肽水平显著低于GADA阴性的T2DM组(P<0.01);GADA阳性T2DM组ICA阳性率增高(P<0.01),体重指数降低(P<0.05).结论:GADA测定对于及早发现T2DM患者胰岛β细胞功能损伤和早期预报LADA有一定意义.
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