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betatrophin ji yin duo tai xing yu 2 xing tang niao bing de xiang guan xing
Author(s): 
Pages: 72-76
Year: Issue:  1
Journal: Journal of Jiangsu University(Medicine Edition)

Keyword:  Betatrophin单核苷酸多态性2型糖尿病;
Abstract: 目的:探讨Betatrophin基因rs2278426多态性与2型糖尿病(T2DM)的相关性。方法:分别选取T2DM患者(T2DM组)和健康者(对照组)各200例,采用聚合酶链式反应—限制性片段长度多态性(PCR-RFLP)技术,对Betatrophin基因rs2278426多态性进行检测。结果:T2DM组Betatrophin基因rs2278426位点C/T+T/T基因型及T等位基因的频率明显高于对照组(P <0. 05)。C/T+T/T基因型携带者空腹血糖及120 min OGTT血糖(2hPG)明显高于C/C基因型携带者(P <0. 05)。Logistic回归分析显示,Betatrophin基因rs2278426 T等位基因相对于C等位基因,增加T2DM的发病风险。结论:Betatrophin基因rs2278426多态性可能与T2DM的发生有关,T等位基因可能增加T2DM的发病风险。
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