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The Relationship between human serum resistin level and Body fat content, plasma glucose as well as blood pressure
Author(s): 
Pages: 1609-1612
Year: Issue:  23
Journal: NATIONAL MEDICAL JOURNAL OF CHINA

Keyword:  血糖高血压胰岛素抵抗;
Abstract: 目的了解高血压病患者血清抵抗素浓度,探讨血清抵抗素水平和体脂含量、血糖及血压的关系.方法酶免疫测定法检测71例高血压病患者(男33例,女38例)的空腹血清抵抗素浓度;口服葡萄糖耐量试验和胰岛素释放试验,测定血浆葡萄糖浓度和血清胰岛素浓度,计算葡萄糖曲线下面积(AUCG)和OGTT开始30分钟胰岛素和血糖变化的比值(ΔI30/ΔG30),根据Cederholm公式计算胰岛素敏感指数(ISI);测量收缩压(SBP)、舒张压(DBP)、身高、体重、腰围、臀围,计算体重指数(BMI)、体内脂肪百分比(BF%)及腰围/臀围比(WHR).结果相关分析显示空腹血清抵抗素浓度与AUCG(r=0.380,P<0.001)及BF%(r=0.353, P<0.01)呈显著正相关,与ISI(r=-0.242, P<0.05)及ΔI30/(G30(r=-0.298, P<0.05)呈显著负相关,与SBP、DBP、BMI及WHR无相关;较正年龄和BMI后偏相关分析显示空腹血清抵抗素浓度与AUCG(r=0.268,P<0.05)仍呈显著正相关,与ΔI30/ΔG30(r=-0.247, P<0.05)仍呈显著负相关,与ISI无相关;多元逐步回归分析表明抵抗素浓度是影响血糖的独立因素.结论血清抵抗素浓度与BF%及血糖浓度的强相关性提示抵抗素可能是人体肥胖与2型糖尿病联系所在.
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