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fei dui cheng er jia ji jing an suan dui xin li shuai jie zuo yong ji zhi ying xiang de yan jiu jin zhan
Author(s): 
Pages: 173-176
Year: Issue:  2
Journal: Research of Traditional Chinese Medicine

Keyword:  心力衰竭二甲基精氨酸二甲胺水解酶1非对称二甲基精氨酸一氧化氮一氧化氮合成酶;
Abstract: 非对称二甲基精氨酸(ADMA)是一种内源性一氧化氮合酶(NOS)抑制剂,可抑制NOS的生物活性,并增加因NOS损耗引起的活性氧自由基产生。血清ADMA不仅是心肌梗死或心力衰竭病人死亡率的强烈预测因子,而且是高血压、冠心病、糖尿病和肾功能不全等影响心力衰竭发生发展的独立危险因素。二甲基精氨酸二甲胺水解酶(DDAH1)是降解ADMA的一种生物酶,在维持一氧化氮(NO)生物活性和保护心血管功能方面起着重要作用。
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