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EXPRESSION AND ITS CLINICAL IMPLICATIONS OF PLATELET-ENDOTHELIUM DERIVED FACTOR IN BREAST CANCER TISSUES
Author(s): 
Pages: 24-26
Year: Issue:  11
Journal: JOURNAL OF POSTGRADUATES OF MEDICINE

Keyword:  乳腺癌免疫组织化学血管生成血小板内皮衍生因子微血管密度;
Abstract: 目的探讨血小板内皮衍生因子(PDGF)在乳腺癌中的表达及与肿瘤血管生成、转移和预后的关系.方法采用免疫组织化学方法检测60例乳腺癌组织中PDGF表达和微血管密度(MVD)分布.结果乳腺癌中PDGF表达阳性率为65.0%,PDGF表达与组织学分级、临床分期、淋巴结转移、远处转移、早期死亡密切相关(P<0.05),与MVD有显著相关性(P<0.05),与肿瘤大小、ER、PR无关(P>0.05).结论 PDGF在乳腺癌血管生成中具有重要作用,PDGF阳性的乳腺癌易发生转移,预后不良.
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