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Clinical study on inversion of colon cancer cells multiple resistance
Author(s): 
Pages: 32-33
Year: Issue:  11
Journal: JOURNAL OF POSTGRADUATES OF MEDICINE

Keyword:  大肠癌多药耐药逆转环孢霉素A他莫昔芬;
Abstract: 目的探讨环孢霉素A(CsA)联合他莫昔芬(TAM)逆转大肠癌多药耐药的临床疗效.方法用免疫组织化学技术对大肠癌的P-蛋白表达进行检测,筛选阳性病例同时进行骨髓微小转移测定,选择二者皆为阳性患者作为研究对象,并随机分为两组,比较CsA联合TAM加化疗组与单纯化疗组疗效.结果在大肠癌中P-蛋白表达阳性率为66.6%(56/84),在p糖蛋白(P-gp)阳性病例中,骨髓微小转移(BMM)阳性率为57.1%(32/56).CsA联合TAM对逆转大肠癌多药耐药有一定作用,加逆转剂组疗效高于不加逆转剂组(P<0.05).结论 CsA联合TAM对逆转大肠癌多药耐药的临床应用安全,且有一定疗效.
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