Enhanced efficiency of stannous penetration and lipopolysaccharide neutralization by a novel stabilized stannous-containing sodium fluoride dentifrice
Author(s): LIU Linhua, SHI Yunming, LI Hongmei, HE Tao, LI Jiahui, HE Yanyan, DONG Weili
Pages: 758-762
Year: 2017 Issue: 6
Journal: Journal of Practical Stomatology
Keyword: Plaque; Stannous; Lipopolysaccharide; Endotoxin; CLSM;
Abstract: Objective:To evaluate the dental biofilm penetration efficiency of a novel stabilized stannous-containing sodium fluoride dentifric(EXP) and its lipopolysaccharide (LPS) neutralization efficiency.Methods:A controlled,randomized,examiner-blind in situ clinical trial was conducted with the treatment of PBS(control),EXP and a marketed stannous-containing sodium fluoride dentifrice (MKD).Fluorescent dye,fluorescent probe and fluorescence colocalization were used for sample examination and analysis.Results:EXP offered better stannous penetration into the biofilm than MKD and PBS(P ＜0.05),as well as greater LPS neutralization efficiency(P ＜0.05).There was a 96.52％ overlap of stannous ions and bounded LPS at the same sites treated by EXP.Conclusion:EXP is more effective than MKD in the delivery of stannous into the biofilm and in the neutralization of LPS.
Pages: 758-762
Year: 2017 Issue: 6
Journal: Journal of Practical Stomatology
Keyword: Plaque; Stannous; Lipopolysaccharide; Endotoxin; CLSM;
Abstract: Objective:To evaluate the dental biofilm penetration efficiency of a novel stabilized stannous-containing sodium fluoride dentifric(EXP) and its lipopolysaccharide (LPS) neutralization efficiency.Methods:A controlled,randomized,examiner-blind in situ clinical trial was conducted with the treatment of PBS(control),EXP and a marketed stannous-containing sodium fluoride dentifrice (MKD).Fluorescent dye,fluorescent probe and fluorescence colocalization were used for sample examination and analysis.Results:EXP offered better stannous penetration into the biofilm than MKD and PBS(P ＜0.05),as well as greater LPS neutralization efficiency(P ＜0.05).There was a 96.52％ overlap of stannous ions and bounded LPS at the same sites treated by EXP.Conclusion:EXP is more effective than MKD in the delivery of stannous into the biofilm and in the neutralization of LPS.
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