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Correlation between exon5 polymorphism of glutathione S-transferase P1 gene and susceptibility to chronic obstructive pulmonary disease in northern Chinese population of Han nationality living in Beijing, China
Author(s): 
Pages: 678-681
Year: Issue:  10
Journal: CHINESE JOURNAL OF INTERNAL MEDICINE

Keyword:  肺疾病阻塞性谷胱甘肽转移酶类多态现象;
Abstract: 目的研究谷胱甘肽S转移酶P1(GSTP1)基因第5外显子多态性(A/G)与北京地区中国北方汉族人群慢性阻塞性肺疾病(COPD)的相关性.方法采用病例-对照研究方法选择97例COPD患者和67例非COPD患者.通过聚合酶链反应-限制性片段长度多态性法检测两组患者GSTP1基因第5外显子各种基因型和等位基因频率.结果两组患者GSTP1基因第5外显子各种基因型频率和等位基因频率的分布差异无显著性 (AA基因型频率:72% vs 61%;等位基因A频率: 84% vs 79%;P>0.05),且两组男性患者GSTP1基因第5外显子各种基因型频率和等位基因频率的分布差异也无显著性 (AA基因型频率:70% vs 58%; 等位基因A频率: 82% vs 78%;P>0.05).结论 GSTP1基因第5外显子多态性(A/G)与北京地区中国北方汉族人群COPD易感性无相关性.
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