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HCPT/PEG-PLA nano micelles for RSCC-1 cells in vitro inhibition experiments
Author(s): MA Ping, LI Qi, JIN Wulong, Department of Stomatology, Inner Mongolia Medical University Affiliated Hospital
Pages: 120-
123
Year: 2018
Issue:
2
Journal: Stomatology
Keyword: hydroxyeamptotheeine nano micelles; tougue squamous carcinoma cell RSCC-1; cytotoxicity;
Abstract: Objective To investigate the inhibitory effect of HCPT/PEG-PLA nano micelles on RSCC-1 cells in vitro. Methods Rabbit tongue cancer cells RSCC-1 were recovered,cultured and passed to the logarithmic growth phase experiment. After co-cultured for different times with PBS group,different concentrations of HCPT group and HCPT/PEG-PLA group,MTT method was used to detect cytotoxic effect in vitro,and cell growth inhibition rate was calculated. Results MTT assay showed that HCPT common dosage group showed significant cytotoxicity and the growth inhibition rate increased with the increase of drug concentration and action time.The growth inhibition rate of HCPT/PEG-PLA nano micelles dosage group at 48 h was less than HCPT common dosage group( P <0.05),and at 96 h,there was no statistical difference compared with HCPT common dosage( P > 0. 05). Conclusions(1) HCPT/PEG-PLA nano micelle has a direct inhibitory effect on the RSCC 1 cells,showing time-and dose-dependent properties.(2) HCPT/PEG-PLA nano micelle has sustained release.
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