Effect of obstructive sleep apnea-hypopnea syndrome on blood glucose, serum lipid, and C-reactive protein levels
Author(s): REN Tao, TANG Yijun, WANG Meifang, LIU Yan, QIAN Xin
Pages: 53-57
Year: 2017 Issue: 6
Journal: Journal of Otolaryngology and Ophthalmology of Shandong University
Keyword: Sleep apnea; obstructive; Hypopnea; Blood glucose; Serum lipid; C-reactive protein;
Abstract: Objective We aimed to assess the correlation between obstructive sleep apnea-hypopnea syndrome ( OSAHS) and changes in blood glucose, serum lipid, and C-reactive protein ( CRP) levels. Methods Based on the apnea-hypopnea index (AHI), 103 patients with OSAHS were divided into 3 groups, with mild (n=36), moderate ( n=35 ) , and severe disease ( n=32 ) . Thirty-five healthy subjects served as controls. Arterial oxygen saturation ( SpO2 ) , blood glucose, serum lipid levels, and CRP levels were compared. We analyzed the correlation between AHI and SpO2 , blood glucose, serum lipid, and CRP levels. Results Compared with the control group, the lowest and av-erage SpO2 levels were significantly lower in all groups of OSAHS (P<0.01). Insulin resistance (IR) was high in all groups;furthermore, the fasting blood glucose (FBG), fasting insulin (FINS), CRP, and serum triglyceride (TG) levels were also significantly higher in these patients (P<0.05). Low-density lipoprotein cholesterol (LDL-C) levels were significantly higher in the moderate and severe groups ( P<0.01) , and increased linearly with the severity of OS-AHS (P<0.01). High-density lipoprotein cholesterol (HDL-C) levels were significantly lower in all OSAHS groups and decreased linearly with disease severity ( P<0.01) . Total cholesterol ( TC) levels were significantly higher in the se-vere group ( P<0.05) , but there was no significant difference between the 4 groups ( P>0.05) . AHI correlated positive-ly with FINS levels and IR ( P<0.01);it did not correlate with the lowest and average SpO2 , FINS levels, and IR ( P>0.05) . AHI correlated negatively with HDL-C levels ( P<0.05) and positively with TG and CRP levels ( P<0.01) . The lowest and average SpO2 correlated positively with HDL-C levels (P<0.05) and negatively with TG and CRP levels ( P<0.01) . Conclusion OSAHS has a strong influence on blood glucose, serum lipid, and CRP levels. The severity of OSAHS is correlated to blood glucose, serum lipid, and CRP levels. In addition, when the severity of OSAHS is based on AHI, low SpO2 is a typical pathological feature in all groups. Besides, AHI is strongly correlated to SpO2 , IR, as well as FINS, HDL-C, TG, and CRP levels. Therefore, early screening for these markers of OSAHS may be signifi-cant in the evaluation of the disease.
Pages: 53-57
Year: 2017 Issue: 6
Journal: Journal of Otolaryngology and Ophthalmology of Shandong University
Keyword: Sleep apnea; obstructive; Hypopnea; Blood glucose; Serum lipid; C-reactive protein;
Abstract: Objective We aimed to assess the correlation between obstructive sleep apnea-hypopnea syndrome ( OSAHS) and changes in blood glucose, serum lipid, and C-reactive protein ( CRP) levels. Methods Based on the apnea-hypopnea index (AHI), 103 patients with OSAHS were divided into 3 groups, with mild (n=36), moderate ( n=35 ) , and severe disease ( n=32 ) . Thirty-five healthy subjects served as controls. Arterial oxygen saturation ( SpO2 ) , blood glucose, serum lipid levels, and CRP levels were compared. We analyzed the correlation between AHI and SpO2 , blood glucose, serum lipid, and CRP levels. Results Compared with the control group, the lowest and av-erage SpO2 levels were significantly lower in all groups of OSAHS (P<0.01). Insulin resistance (IR) was high in all groups;furthermore, the fasting blood glucose (FBG), fasting insulin (FINS), CRP, and serum triglyceride (TG) levels were also significantly higher in these patients (P<0.05). Low-density lipoprotein cholesterol (LDL-C) levels were significantly higher in the moderate and severe groups ( P<0.01) , and increased linearly with the severity of OS-AHS (P<0.01). High-density lipoprotein cholesterol (HDL-C) levels were significantly lower in all OSAHS groups and decreased linearly with disease severity ( P<0.01) . Total cholesterol ( TC) levels were significantly higher in the se-vere group ( P<0.05) , but there was no significant difference between the 4 groups ( P>0.05) . AHI correlated positive-ly with FINS levels and IR ( P<0.01);it did not correlate with the lowest and average SpO2 , FINS levels, and IR ( P>0.05) . AHI correlated negatively with HDL-C levels ( P<0.05) and positively with TG and CRP levels ( P<0.01) . The lowest and average SpO2 correlated positively with HDL-C levels (P<0.05) and negatively with TG and CRP levels ( P<0.01) . Conclusion OSAHS has a strong influence on blood glucose, serum lipid, and CRP levels. The severity of OSAHS is correlated to blood glucose, serum lipid, and CRP levels. In addition, when the severity of OSAHS is based on AHI, low SpO2 is a typical pathological feature in all groups. Besides, AHI is strongly correlated to SpO2 , IR, as well as FINS, HDL-C, TG, and CRP levels. Therefore, early screening for these markers of OSAHS may be signifi-cant in the evaluation of the disease.
Related Articles