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Effects of different dosage forms of oryzanol on efficacy,sex hormones levels and quality of life in patients with climacteric syndrome:a comparative study
Author(s): 
Pages: 1150-1153
Year: Issue:  8
Journal: Guangxi Medical Journal

Keyword:  Climacteric syndromeOryzanolSex hormonesQuality of lifeEfficacyDosage form;
Abstract: Objective To compare the effects of oryzanol injection and tablets on the efficacy,sex hormones levels and quality of life in patients with climacteric syndrome.Methods A total of 114 patients with climacteric syndrome were selected and were divided into observation group(n=57) and control group(n=57) using random number table.The control group and the observation group were given oryzanol tablets and injection respectively.The efficacy,sex hormones levels,quality of life,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the serum estradiol(E2) level increased significantly but the levels of follicle-stimulating hormone(FSH) and luteinizing hormone(LH) decreased in the two groups compared to the pre-treatment,and the observation group had higher level of E2 and lower levels of FSH and LH compared to the control group(all P<0.05).After treatment,the scores of all dimensions of Menopause-Specific Quality of Life(MENQOL) questionnaire decreased significantly in the two groups compared to the pre-treatment,and the vasomotor and physiological scores in the observation group were lower than those in the control group (P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Oryzanol injection has a definite efficacy on climacteric syndrome.It,which is of good safety,obtains better effects on patients′ sex hormones levels and quality of life compared to oryzanol tablets.
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