The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Bookmark and Share
Anti-cancer effects of Alternol and Alteronol on human cancers
Pages: 452-455
Year: Issue:  6
Journal: Journal of International Oncology

Abstract: Alternol and Alteronol are two small chemical compounds purified from a mutant fungal.The in vitro and in vivo experimental studies have confirmed their potent anti-cancer effect.In vitro studies show that they can inhibit cell division and proliferation of a variety of tumors including prostate cancer,osteosarcoma and melanoma.They exert their anti-cancer effects by attenuating cell cycle protein expression and causing cell cycle arrest,suppressing tumor cell invasion and metastasis,reducing new blood vessel formation,decreasing the expression of anti-apoptotic proteins Bcl-2 in malignant cells,and stimulating oxygen free radical accumulation.However,there is no significant cytotoxic effect on benign cells.Animal experiments show that these two compounds significantly inhibit xenograft growth derived from a variety of human malignant tumors,while there is no obvious side effect on normal tissue or organs.In conclusion,these two compounds are worthy to be developed as novel anti-cancer drugs.
Related Articles
No related articles found