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The research of process rationality of cefpiramide for injection
Pages: 465-469
Year: Issue:  6
Journal: Chinese Journal of Antibiotics

Abstract: Objective To investigate three kinds of processes' rationality of the cefpiramide for injection.Method To evaluate difference processes' rationality of the cefpiramide for injection,by testing the impurities,dissolution time,solid stability,stability of solution,adding pharmaceutical excipient rationality and clinical adverse events of difference processes.Results Cefpiramide for injection,which add anhydrous sodium carbonate in the process,dissolution time was longer;cefpiramide sodium for injection,which add sodium benzoate in the process,impurities growing fast in the solid test,and it would bring some sort of risk;cefpiramide sodium for injection,prepared by solvent crystallization,without adding other materials,not only have a high purity,but also have a better stability.Conclusion Cefpiramide sodium for injection,prepared by solvent crystallization,is relatively safter.And the quality of this process is more controllable.
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