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Role of IL-17 in the formation and invasion of lymphatic vessels in NSCLC
Pages: 551-554
Year: Issue:  5
Journal: Oncology Progress

Abstract: Objective To investigate the role of interleukin-17 (IL-17) in the formation and invasion of lymphatic vessels in non small cell lung cancer (NSCLC). Method 40 cases of NSCLC specimens were collected, in which the ex-pression of IL-17 and lymphatic vessel density were detected by immunohistochemistry;the effect of IL-17 on the prolif-eration of lymphatic endothelial cells (LEC) was detected by MTT assay, and the effect of IL-17 on migration and tube like structure formation of LEC cells was detected by Transwell assay and lymphatic vessel formation assay. Result The lymphatic vessel density in patients with positive expression of IL-17 was significantly higher than that in those with neg-ative expression of IL-17 (P<0.05);IL-17 at 0, 0.5, 1.0, 5.0 and 10.0 ng/ml had similar effect on the proliferation activity of LEC cells (P>0.05);there was no significant difference in transmembrane cell number between control group and IL-17 group (P>0.05);the number of transmembrane cells in LLC group was (58.70±12.52), which was significantly higher than that in control group and IL-17 group (P<0.05); the number of transmembrane cells in LLC+IL-17 group was (98.82 ± 20.16), which was significantly higher than that in other groups (P<0.05);there was no significant difference in the number of tube like structures between control group and IL-17 group (P>0.05);the number of tube like structures in LLC group was significantly higher than that in control group and IL-17 group (P<0.05), and was the highest in LLC+IL-17 group at (155.82±29.92) compared with other groups (P<0.05). Conclusion IL-17 does not directly influence the pro-liferation, migration and tube like structure formation of LEC, but it can promote the lymph node metastasis of the cell by action on NSCLC cells.
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