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Analysis of clinical efficacy of neoadjuvant chemotherapy in locally advanced cervical cancer
Pages: 501-504
Year: Issue:  5
Journal: Oncology Progress

Abstract: Objective To investigate the efficacy of neoadjuvant chemotherapy in stageⅠ b2~Ⅱb cervical cancer pa-tients. Method The medical records of 84 stage Ib2~Ⅱb cervical cancer patients who had undergone surgery were retro-spectively analyzed. All these patients were treated with one to three courses of venous chemotherapy or arterial chemo-therapy before surgery. The efficacy of neoadjuvant chemotherapy was assessed by comparing and analyzing the progress of the lesion before and after chemotherapy, the serum levels of squamous cell carcinoma antigen (SCC-Ag), and the 3-year disease-free survival (DFS) and overall survival after surgery. Result Of the 84 patients, the effective rate of chemo-therapy was 82.1%, 5 patients achieved complete response, 64 patients achieved partial response, 13 patients had stable disease, and 2 patients had progressive disease. The effect of chemotherapy was not correlated with clinical stage, patho-logical type and tumor size (P>0.05);the SCC-Ag levels decreased significantly after the treatment of neoadjuvant chemo-therapy (P<0.001). Both the 3-year overall survival rate and disease-free survival rate were both 93%. Conclusion Neo-adjuvant chemotherapy is safe and effective, can significantly reduce tumor size and improve prognosis in patients with cervical cancer. It has significant therapeutic values.
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