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The efficacy of intensity-modulated radiation therapy in patients with cervical cancer and pelvic lymph node metastases
Pages: 521-523,527
Year: Issue:  5
Journal: Oncology Progress

Abstract: Objective To investigate the clinical effect of intensity-modulated radiation therapy (IMRT) in patients with cervical cancer and pelvic lymph node metastases. Method The clinical data of 94 patients with cervical cancer were retrospectively analyzed, in which 47 patients were treated with IMRT (IMRT group), and another 47 patients were treated with conventional radiotherapy (conventional radiotherapy group). The 3-month short-term efficacy, acute adverse reactions and 3-year survival in the two groups were compared and analyzed. Result After 3 months of treatment, the proportion of disappeared or subsided pelvic lymph nodes in IMRT group was higher than that in the conventional radio-therapy group (P<0.05). There were 29 cases of death in the IMRT group in 3 years, with a cumulative survival rate of 38.3%, and that were 34 cases and 27.7%in the conventional radiotherapy group, besides, the median survival time was 29 (23-35) months in IMRT group, which was significantly longer than that in the conventional radiotherapy group at 13 (7-20) months (P<0.05). In the IMRT group, digestive system adverse reactions and bone marrow suppression were signif-icantly reduced (P<0.01), and no adverse reactions of grade 3 occurred in the IMRT group. Conclusion IMRT can not only increase the radiation dose of tumor tissues, but also improve the curative effect, and thus reduces the incidence of acute adverse reactions and prolongs the 3-year median survival time after treatment.
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