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The correlation between EGFR mutation and the biological behavior of lung cancer patients with malignant pleural effusion
Pages: 544-546
Year: Issue:  5
Journal: Oncology Progress

Abstract: Objective To investigate the relationship between the mutation of epidermal growth factor receptor (EGFR) gene and the biological behavior of lung cancer patients with malignant pleural effusion. Method 100 patients with lung cancer, including 43 cases with malignant pleural effusion (study group), and 57 patients without pleural effu-sion (control group), were observed for the EGFR mutation status. Result The overall EGFR mutation rate in the study group was 72.09%, significantly higher than that of the control group at 19.30%(P<0.05);the EGFR mutation rate of pa-tients with high, moderate and low differentiation in study group was 69.23%, 71.43%and 77.78%, which were signifi-cantly higher than those in the control group, respectively (P<0.05);gender, age, smoking status and differentiation de-gree were independent of the EGFR mutation rate in study group (P>0.05);the Kappa value of the EGFR gene test results obtained from pleural effusion and biopsy specimens was 0.466 (P<0.05), indicating a moderate consistency. Conclusion EGFR mutation rate is higher in lung cancer patients with malignant pleural effusion, but is not associated with gender, age , smoking status and differentiation degree.
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