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Genetic polymorphisms of TLR4 genes and prostate cancer risk in Chinese Han population
Pages: 537-539,543
Year: Issue:  5
Journal: Oncology Progress

Abstract: Objective To explore the association between single nucleotide polymorphisms (SNP) of Asp299Gly (rs4986790), Thr399Ile (rs4986791), rs11536889 and the susceptibility and severity of prostate cancer. Method In this case-control study, 96 patients with histological evidence of prostate cancer (PCa group), 87 patients with benign prostatic hyperplasia (BPH group) and 92 cases of healthy control subjects (control group) were enrolled. Clinical data and Glea-son's score were recorded. Genotypes were determined using PCR-RFLP analysis. Result The PCa, BPH and control group were significantly different in age, family history of prostate cancer and prostate-specific antigen levels (P=0.000);while there were no significant differences of Asp299Gly and Thr399Ile genotype frequency in the three groups, but not for rs11536889 SNP [PCa/(BPH+control), CC/GC vs GG, OR=2.152, 95%CI:1.280-3.618, P<0.05];and GC+CC was high-er in the subgroup with Gleason's score≥7 than that with Gleason's score<7 (OR=2.378, 95%CI:1.042-4.427, P<0.05). Conclusion rs11536889 SNP with TLR4 gene may be associated with the occurrence and aggravation of prostate cancer.
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