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Clinical study on correlation between type 2 diabetes mellitus or impaired glucose tolerance and hepatocellular carcinoma in patients with hepatitis B cirrhosis
Pages: 540-543
Year: Issue:  5
Journal: Oncology Progress

Abstract: Objective To investigate the effect of type 2 diabetes mellitus or impaired glucose tolerance on the pro-gression and prognosis of patients with hepatitis B cirrhosis. Method 92 patients with hepatitis B cirrhosis were enrolled and divided into three groups according to their blood glucose values:normal glucose metabolism group (25 cases), type 2 diabetes mellitus group (40 cases) and impaired glucose tolerance group (27 cases). The clinical data (gender, age, plate-let count, albumin level, Child grade, HBeAg positive rate, HBV DNA and number of antiviral treatments) were recorded during the study period, and the incidence of cirrhosis complications, the incidence of hepatocellular carcinoma and mor-tality of different groups in 1 to 4 years were recorded. Result There were statistically significant differences in inci-dence of cirrhosis complications, incidence of hepatocellular carcinoma and mortality between normal glucose metabo-lism group and type 2 diabetes mellitus group or impaired glucose tolerance group (P<0.05). The incidence of cirrhosis complications, incidence of hepatocellular carcinoma and mortality in type 2 diabetes mellitus group were all higher than those in normal glucose metabolism group. There were statistically significant differences in the incidence of cirrhosis complications, incidence of hepatocellular carcinoma and mortality in patients with type 2 diabetes mellitus between dis-ease course<3 years group and 3 to 8 years group or>8 years group (P<0.05). The incidence of cirrhosis complications, incidence of hepatocellular carcinoma and mortality in disease course >8 years group were all higher than those in <3 years group (P<0.05). Multivariate Logistic regression analysis showed that Child score, type 2 diabetes, albumin>18 g/L, HBeAg positive and HBV DNA≥2 × 105 U/ml were risk factors of hepatocellular carcinoma in patients with hepatitis B cirrhosis. Conclusion Abnormal glycometabolism is closely related to the hepatocellular carcinoma in patients with hep-atitis B cirrhosis. Type 2 diabetes mellitus may be an early warning signal for hepatocellular carcinoma in patients with hepatitis B cirrhosis.
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