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Expression and clinical significance of mTOR and survivin in gliomas
Pages: 559-561,568
Year: Issue:  5
Journal: Oncology Progress

Abstract: Objective To study the expression level and clinical significance of mTOR and survivin in human glio-ma. Method 89 cases of glioma (study group) and 10 cases of cerebral decompression due to traumatic brain injury (con-trol group) were included in the study;according to the pathological examination results of gliomas, 89 patients in study group were stratified as lower grade group (grade I:20 cases, grade II:24 cases) and higher grade group (grade III:21 cas-es, grade IV:24 cases);the specimens of glioma of study group and normal brain tissues of control group were collected and detected by immunohistochemistry for mTOR and surviving, and the correlation with clinical features were investigat-ed. Result No positive expression of mTOR and survivin were observed in the control group, while those in higher grade group were higher than that in the lower grade group (P<0.05);a positive correlation between pathological grading and expression of mTOR and survivin were observed (r=0.443, P=0.000; r=0.379, P=0.000); besides, mTOR and sur-vivin expression were varied in patients with different pathological grade and tumor size (P<0.05), while survivin level was also associated with pathological types (P<0.05);mTOR and survivin were positively correlated with each other in gliomas (r=0.279, P<0.05). Conclusion mTOR and survivin expression are markedly enhanced in gliomas, and are in-creased as pathological grade elevates, indicating a key role in the development of glioma, which may provide scientific guidance for clinical targeted therapy.
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