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Clinicopathological features of endometriosis-associated ovarian clear cell carcinoma and ovarian endometrioid carcinoma
Pages: 572-575
Year: Issue:  5
Journal: Oncology Progress

Abstract: Objective To study the clinicopathological features of endometriosis (EM)-associated ovarian clear cell carcinoma (CCC) and ovarian endometrioid carcinoma (EC). Method A total of 167 cases of CCC and EC patients were included in the study, stratification were performed based on patients with (EM group, n=84) or without (non EM group, n=83) malignant transformation of EM, of which the age, reproductive history, history of EM, clinical manifestations, blood coagulation function, serum CA125 level, ultrasound findings, intraoperative and postoperative pathological charac-teristics were compared. Result Patients in EM group had lower age of onset, and age at menarche than non EM group (P<0.01), with lower proportion of premenopausal patients (P<0.01), less gravidity and parity (P<0.001), higher rate of in-fertility (P<0.001), more patients with a history of EM (P<0.05) compared with non EM group;as for clinical manifesta-tions, higher incidence of dysmenorrhea, menstrual disorders (P<0.01), and shorter PT and APTT (P<0.001) were ob-served in EM group compared with non EM group;after surgery, the serum level of CA125 was lower in EM group than that of non EM group (P<0.05); while the ultrasound findings were comparable between the two groups (P>0.05); EM group had larger tumor diameter than non EM group (P<0.001); and the difference of FIGO staging between the two groups was statistically significant (P<0.05), in which the proportion of patients with stage Ⅰ-Ⅱwas lower in EM group than that in non EM group. Conclusion The clinicopathological features of EM associated CCC and EC were different with that of simple CCC and EC, with the characteristics of lower age at diagnosis and age at menarche, higher proportion of menopause, less gravidity and parity, more patients with history of EM, higher rate of dysmenorrhea and menstrual dis-orders, shorter PT and APTT, lower levels of serum CA125 and lower clinical stage.
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