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Clinical value of preoperative peripheral blood neutrophil-to-lymphocyte ratio in evaluating patient prognosis after radical resection of hepatocellular carcinoma
Pages: 592-595
Year: Issue:  5
Journal: Oncology Progress

Abstract: Objective To evaluate the clinical value of preoperative peripheral blood neutrophil-to-lymphocyte ratio (NLR) in evaluating patient prognosis after radical resection of hepatocellular carcinoma (HCC). Method The clinical data of 161 patients with HCC who had undergone radical resection of HCC were collected, and the patients were divided into high NLR group (NLR≥2.60,n=52) and low NLR group (NLR<2.60,n=109) according to the preoperative NLR val-ue. The survival rate was analyzed using Kaplan-Meier method, and the difference was checked by Log-rank test. The Cox regression model was used to analyze the prognostic factors for overall survival rate in patients with HCC. Result The median follow-up time of the 161 HCC patients was 29 months. The overall 1-, 3-, and 5-year survival rates of the high NLR group were 79.6%, 70.8%and 41.1%, respectively, and the median time to tumor recurrence was 14.9 months. The overall 1-, 3-, and 5-year survival rates of low NLR group were 90.4%, 79.6%, 48.7%, and the median time to tumor recurrence time was 20.1 months. The overall 1-, 3-, and 5-year survival rates of the high NLR group were all lower than those of the low NLR group (P<0.05), and the median time to tumor recurrence was shorter than that of low NLR group (P<0.05). The results of univariate analysis showed that tumor envelope, TNM staging, preoperative AFP, preoperative high NLR, lymph node metastasis, and tumor size were related to the prognosis and survival time after radical resection of HCC, and the differences were statistically significant (P<0.05). The results of Cox multivariate analysis showed that stageⅢ-Ⅳin TNM staging system, preoperative AFP<400 ng/ml, preoperative NLR≥2.60, lymph node metastasis, tu-mor size≥10 mm were the independent prognostic factors for patients after radical resection of HCC (P<0.001). Conclu-sion Preoperative NLR is an independent risk factor for the prognosis of patients after radical resection of HCC. It can be used as an indicator to evaluate the prognosis of patients, and the prognosis of patients with high preoperative NLR is poor.
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