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Progress in research on necroptosis as a target for cancer radiotherapy and chemotherapy
Pages: 220-226
Year: Issue:  3
Journal: International Journal of Radiation Medicine and Nuclear Medicine

Abstract: A characteristic of cancer is resistance to programmed cell death,which sustains cell survival through oncogenic transformation and therapeutic resistance.Recent studies have shown that programmed cell death is not limited to caspase-dependent apoptosis.Necroptosis,a caspase-independent form of cell death,is regulated by receptor interacting protein 1,receptor interacting protein 3,and mixed lineage kinase domain-like proteins.This review summarized current research studies on necroptosis to provide perspectives for the development of novel tumor radiotherapy and chemotherapy strategies that target this process.
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