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shi guan wei jiao jie bu xian ai xin fu zhu hua liao liao xiao yu ce yin zi de lin chuang yan jiu
Pages: 243-245
Year: Issue:  3
Journal: Journal of Basic and Clinical Oncology

Abstract: 目的 探讨P53、Ki-67、MRP在(AEGJ)组织中的表达情况及在SOX方案新辅助化疗疗效中的预测价值.方法 98例进展期AEGJ患者均行SOX方案新辅助化疗,并用免疫组化方法检测P53、Ki-67、多药耐药相关蛋白(MRP)的表达情况,分析各蛋白表达与化疗疗效的关系.结果 本组患者新辅助化疗有效率为48.0%.P53、Ki-67和MRP的阳性率分别为32.6%、59.2%和34.7%.P53和Ki-67的表达与化疗敏感性有关(P<0.05),但MRP的表达与化疗敏感性无关(P>0.05).结论 P53低表达和Ki-67高表达是AEGJ患者SOX方案新辅助化疗敏感性的影响因素,两者表达情况可为AEGJ个体化新辅助化疗方案的选择提供有益的参考.
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