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Liver fat quantitative measurement on rabbit NAFLD model using dual-energy CT and 3.0T MRI
Pages: 441-446
Year: Issue:  5
Journal: Radiologic Practice

Abstract: Objective:To investigate the accuracy of dual-energy CT and MRI in the quantitative diagnosis in fatty livor.Methods:50 adult male New Zealand white rabbits were randomly divided into 2 groups:group A (n=42) and group B (n=8).In group A,rabbits were fed with high-fat diet;whereas in group B,rabbits were fed with regular diet,both for 16 weeks.Dual-energy CT scan,MRI three-dimensional in phase and out of phase and IDEAL-IQ were performed at different times after feeding.CT value on different monochromatic energy image of DECT,hepatic fat fraction (HFF) on in phase and out of phase of MRI and proton density fat fraction (PDFF) on IDEAL-IQ of MRI were all measured.After CT and MRI scan,liver pathologic samples were obtained and liver fat content was obtained by using acid-catalyzed hydrolysis method.Spearman correlative analysis was used in the evaluation of correlations among each parameter and pathology results.Results:There was statistical significant difference in CT values,PDFF and HFF among different liver fat content pathological grades (P<0.05) in control group.Spearman correlation analysis showed a negative correlation between CT values and pathological results,and a positive correlation between PDFF,HFF and pathological results (P<0.05).CT value on 80keV had the best correlation with pathological results in CT examination,the correlation coefficient was-0.870.PDFF had the best correlation with pathological results in MRI examination,the correlation coefficient was 0.936,higher than HFF (r=0.853).Conclusion:Correlation between PDFF of IDEAL-IQ sequence and pathological results was stronger than that between dual-echo sequence and dual-energy CT.
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