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Evaluation of shear wave elastography in diagnosing fatty liver
Pages: 462-465
Year: Issue:  5
Journal: Radiologic Practice

Abstract: Objective:To investigate the change of fatty liver stiffness by real time shear wave elastography (SWE),and to obtain the diagnostic threshold of fatty liver by comparing with conventional two-dimensional ultrasound and MR mDixon sequence which were used to detect the liver fat content.To analyze the correlation between fatty liver stiffness and fat content.And to assess the value of ultrasound SWE technique in diagnosis of fatty liver.Methods:28 healthy volunteers were examined by conventional two dimensional ultrasound,SWE and MR mDixon sequence.The consistency between the observers of SWE technique was examined by the Bland-Altman plot.The repeatability within the observers of the SWE technique was examined by calculating Pearson correlation coefficient r1、r2.The consistency of the ultrasound SWE techniques,MR mDixon sequence and traditional ultrasound in the detection and grade of fatty liver were analyzed to obtain the diagnostic threshold (kPaMean) combined with the scatter plot.To analyze the correlation of two imaging methods by calculating the Pearson correlation coefficient.The correlation of two imaging methods were analyzed by calculating the Pearson correlation coefficient.Results:Bland-Altman plot showed that 24 cases were within the 95 % agreement limit in 26 healthy volunteers.Intra-group correlation coefficients were r1=0.917,r2 0.921 (P<0.05).Kappa values of kPaMean =4,5,6 were calculated respectively.When Young's modulus diagnostic threshold (kPaMean) was seted at 5kPa,Kappa value=0.819 >0.75 (P<0.05).Pearson correlation coefficient was r hardness-0.877>0.85,r velocity=0.867>0.85,with a significantly statistical difference (all P<0.05).Conclusion:SWE imaging technique can be applied to the measurement of fatty liver with good stability,it can be used not only in clinical detection of fatty liver,but also can provide information about liver stiffness in patients with fatty liver,and it has a high correlation with liver fat content detected by MR mDixon sequence.
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