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Multi-parameter magnetic resonance imaging in the diagnosis of glioma and its correlation with Ki-67
Pages: 483-487
Year: Issue:  5
Journal: Radiologic Practice

Abstract: Objective:To explore the value of multi-parameter magnetic resonance imaging in the diagnosis of glioma and its correlation with Ki-67.Methods:31 patients with glioma proved by surgery and pathology were analyzed retrospectively.According to the classification and grading standard of tumors of the central nervous system (CNS) (WHO 2016 version),18 cases were rated as high-grade gliomas (Ⅲ ~ Ⅳgrade) and 13 cases were identified as low-grade gliomas (Ⅰ ~ Ⅱ grade).All the patients had cerebral pre-contrast MRI images (Ax T1WI/T2 WI/FLAIR T2 WI/DWI/Sag T1WI),enhanced-MRI images,multi-voxel MRS and DTI.Post-processing was carried out in the workstation and ADC value,DCavg value,FA value,Cho/Cr and Cho/NAA ratio of lesions were acquired.Results:There was statistical significant difference in ADC value,Cho/Cr ratio,Cho/NAA ratio and Ki-67 index between high-grade and low-grade gliomas (P < 0.05).There was no statistical significant difference in both DCavg value and FA value (P > 0.05).Ki-67 index showed a negative correlation with ADC value (r =-0.442,P < 0.05);however,Ki-67 showed a positive correlation with Cho/Cr and Cho/NAA value,respectively (r =0.596 and r =0.448,respectively,P < 0.05).There was no correlation between Ki-67 index and DCavg and FA value,respectively (r =-0.101,P =0.589,and r =0.147,P =0.429,respectively).Conclusion:Multi-parameter magnetic resonance imaging can not only help to preoperatively grade glioma,but also evaluate tumor cell proliferative activity,it has more important clinical value.
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