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Quantitative analysis of fatty liver in rats with single-source dual-energy CT:a multi-parameter study
Pages: 475-478
Year: Issue:  5
Journal: Radiologic Practice

Abstract: Objective:To evaluate the degree of fat content in a rat model of fatty liver by using multiple-parameter imaging on single-source dual energy CT (DECT).Methods:Thirty-two SD rats were randomly divided into two groups:experimental group (n =24) and control group (n =8).From the 5th week after being fed,3 rats from experimental group and 1 rat from control group underwent DECT scanning weekly.The pathological degree of fatty liver was evaluated after taking euthanasia in rats.The ratio of liver to spleen CT value (liver/spleen CT value) at 5keV interval from 40 to 140keV,and the spectral curve slope were calculated,recorded and statistically analyzed.Results:There was statistical significant difference in CT value at 70keV and in the slope of the spectral curve between different degrees of fatty liver (P < 0.05).Except the liver/spleen CT value at 70keV between grade 0 and 1,and between grade 2 and 3,the differences in liver/spleen CT value at 70keV and in the slope of the spectral curve between each two groups were all statistically significant (P < 0.05).There were good correlations between the degree of fatty liver and the ratio of liver/spleen CT value at 70keV,and between that and the slope of the spectral curve,with a coefficient of-0.784 and 0.878,respectively (P < 0.05).Conclusion:DECT with multi-parameter imaging can be used to quantitatively evaluate the degree of fatty liver in rat model.
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