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The correlation of visceral adipose tissue volume and other routine obesity indexes with non-alcoholic fatty liver disease
Pages: 436-440
Year: Issue:  5
Journal: Radiologic Practice

Abstract: Objective:To investigate the correlation of visceral adipose tissue (VAT) volume,epicardial adipose tissue (EAT) volume,abdominal subcutaneous adipose tissue (SAT) volume,the maximum and the minimum abdomen diameter at the navel level,body mass index (BMI),waist circumference (WC),SAT fat density,blood triglyceride (TG),and blood cholesterol (CH) with non-alcoholic fatty liver disease (NAFLD),respectively.Methods:Forty-four patients included in this study were divided into two groups:fatty liver group (n=11) and control group (n =33).All subjects underwent unenhanced CT scan of chest and abdomen.Patients' height,weight,gender,age,recent results of blood TG &CH,history of chronic diseases,alcohol drinks and medication were all collected and recorded.The non-alcoholic fatty liver (NAFLD) was defined as the ratio of mean CT value of liver to spleen (CTL/s) less than 1 (CTL/s<1) on unenhanced CT images.The EAT volume,VAT volume,SAT volume,WC,the maximum diameter &the minimum diameter of abdomen at the navel level and abdominal subcutaneous adipose tissue thickness were all semi-automatically measured on CT images using software cardiac risk.Statistics were done to analyze the correlation of the above indexes and CTL/s,and the difference of the indexes in fatty liver and control group was compared.Furthermore,the receiver operating characteristic curve (ROC) was used to measure the diagnostic efficiency of those indexes with statistical significance in predicting NAFLD.Results:The VAT volume had a fair correlation with CTL/s (r=0.551,P<0.001);the subcutaneous adipose tissue density,the minimum diameter at the navel level and the blood TG had a weak correlation with CTL/s (r=0.375,P =0.012;r=0.390,P =0.0009;r=0.471,P=0.001).None of the other indexes correlated with CTL/s significantly (P>0.05).The VAT volume had the biggest area under the curve (AUC) of 0.799 with 95% confidence interval (CI) of 0.670~0.927.The AUC of minimum diameter at the navel level and blood TG was 0.749 (95%CI of 0.598~0.901) and 0.700 (95%CI of 0.496~0.904),respectively.The difference in AUC among these three indexes was not significant (P>0.05).Conclusion:The VAT volume correlates with NAFLD better than those clinical routine indexes (SAT,BMI,WC,etc).It can better predict the risk of NAFLD.
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