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The prediction of renal function recovery in hydronephrosis by using intravoxelIncoherent motion MR imaging
Pages: 509-514
Year: Issue:  5
Journal: Radiologic Practice

Abstract: Objective:To investigate the value of intravoxel incoherent motion MR imaging in predicting renal function recovery in hydronephrosis.Methods:Left side hydronephrosis model of healthy New Zealand rabbits made by ureteral incomplete obstruction were scanned by intravoxel incoherent motion MR imaging at 4,8,12,16 weeks,and the changes of MRI IVIM quantitative parameters (ADC values,D values,D* values,f values) in left hydronephrosis kidney were observed and the parameters were correlated with GFR and pathology.The effect of ADC value,D value,D* value and f value in predicting renal function recovery in hydronephrosis after obstruction relief was explored.Results:ADC values,D,D* values,f values at cortex and medulla in left hydronephrosis model of rabbits reduced gradually with renal damage aggravating after 4,8,12,16 weeks.There was statistical significant difference between group 12 weeks,16 weeks and control group,group 4 weeks;between group 8 weeks and group 16 weeks for D value,f value and ADC values by LSD contrast.There was also statistical significant difference between group 8 weeks,12 weeks,16 weeks and control group,group 4 weeks;between group 8 weeks and group 16 weeks for D* value by LSD contrast.ADC values,D,D* values,f values were moderate positive correlated to GFR and related to pathological changes at 4,8,12,16 weeks for left hydronephrosis model of rabbits.Renal function in hydronephrosis had recovery in different degree after obstruction relief for rabbit before 8 weeks.ADC value,D value,D* value and f value in renal cortex and medulla were of definite value to monitoring renal function recovery,and the best threshold was (2.59± 0.64) × 10-3 mm-2/s,(1.67 ± 0.69) × 10-3 mm-2/s,(16.95 ± 8.32) × 10 3mm-2/s,(0.44 ± 0.18) respectively.Conclusion:Intravoxel incoherent motion MR imaging could monitor dynamic impairment of renal function in hydronephrosis and predict the recovery of renal function after removing obstruction.
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