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CT imaging findings and pathologic correlation of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusions
Pages: 504-508
Year: Issue:  5
Journal: Radiologic Practice

Abstract: Objective:To investigate the CT imaging feature and pathologic correlation of the renal cell carcinoma associated with Xpl1.2 translocation/TFE3 gene fusions.Methods:Complete CT imaging data of 27 patients with renal cell carcinoma associated with Xpl1.2 translocation/TFE3 gene fusions were collected.The clinical,pathological and CT imaging features were analyzed,and the related literatures were reviewed.Results:Fourteen cases were men,thirteen cases were women.The average age was 49.7 years (age range 16 ~ 88 years).Mean value of maximum diameter of the tumor was 5.59cm (ranging from 2.0 to 15.2cm).15 tumors were oval,12 tumors were irregular;11 tumors were solid,16 tumors were cystic-solid.CT plain scan showed calcification in 8 lesions.The density in 11 lesions was uniform,they showed mostly mild or mild-to-moderate enhancement after contrast injection.The solid component of 16 cystic-solid lesions showed intensive enhancement after contrast injection,these were nodular,septate or heterogeneous at the border.There was invasion of adjacent viscera in 3 cases,lymph node metastasis in 3 cases and vascular invasion in 4 cases.Conclusion:The renal cell carcinoma associated with Xpll.2 translocation/TFE3 gene fusions are usually large,calcification,hemorrhage,necrosis and cystic change are common,solid composition of the lesions shows a variety of enhancement after contrast administration,and these are related to the tumor cell composition,arrangement and blood supply of the tumor.
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