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zhong liu huai si yin zi - biao da yu nao chu xue huan zhe shen jing xi bao diao wang de xiang guan xing yan jiu
Pages: 62-63
Year: Issue:  12
Journal: Chinese Journal of Practical Nervous Diseases

Abstract: 目的 探讨脑出血患者炎性因子表达与细胞凋亡的关系.方法 选取脑出血患者48例,登记临床资料并检测血肿周围脑组织TNF-α的不同时间段的表达.测定TNF-α表达:(1)Western Blot法;(2)免疫组化法.测定细胞凋亡:TUNEL法.结果 TNF-α的表达高峰期为0~24 h、13~48 h,TUNEL法测定神经细胞凋亡高峰期为13~48 h,表明脑出血后神经细胞凋亡与TNF-α的表达高峰完全一致,存在时间变化规律一致性.以凋亡细胞数为纵轴,TNF-α表达阳性细胞数为横轴制作散点图.胞质TNF-α阳性细胞数与凋亡细胞数相关系数r为0.954,呈明显正相关.结论 脑出血患者血肿周围脑组织TNF-α表达水平与神经细胞凋亡数一致.
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