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xing nao jing zhu she ye lian he ao ka xi ping dui zuo zuo huan zhe t lin ba xi bao ya qun ji xue qing alp icam-i shui ping bian hua ying xiang
Pages: 88-90
Year: Issue:  12
Journal: Chinese Journal of Practical Nervous Diseases

Abstract: 目的 探讨醒脑静注射液联合奥卡西平对癫痫患者T淋巴细胞亚群及血清碱性磷酸酶(ALP)、细胞间黏附分子(ICAM-I)水平变化影响.方法 选取2014-10-2016-11我院收治的86例癫痫患者,随机数字表法分为2组各43例.对照组给予奥卡西平,研究组给予醒脑静注射液+奥卡西平,2组均治疗3个月.统计2组临床疗效、T淋巴细胞亚群指标(CD3+、CD4+、CD8+)与ALP、ICAM-I变化情况、不良反应发生情况.结果 研究组治疗有效率(97.67%)高于对照组(74.42%),差异有统计学意义(P<0.05);治疗后研究组CD3+、CD4+水平高于对照组,CD8+水平低于对照组,差异有统计学意义(P<0.05);治疗后研究组ICAM-I水平低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率(13.95%)与对照组(18.60%)相比,差异无统计学意义(P>0.05).结论 醒脑静注射液联合奥卡西平治疗癫痫患者可改善T淋巴细胞亚群、降低ICAM-I水平,且临床疗效显著,安全性较高.
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