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Association of CDH17 and LRP1B gene polymorphisms with delayed encephalopathy after carbon monoxide poisoning
Pages: 18-22
Year: Issue:  12
Journal: Chinese Journal of Practical Nervous Diseases

Abstract: Objective To investigate the association of CDH17 (cadherin-17) and LRP1B (low density lipoprotein receptor-related protein 1B) gene polymorphism with delayed encephalopathy after carbon monoxide poisoning.Methods The DEACMP patients were collected from June 2014 to June 2016.The patients were divided into DEACMP group and ACMP group.The CDH17 gene locus (rs2513796) and LRP1B locus (rs1541976,rs10183908) SNP typing were detected in two groups.Results LRP1B gene locus (rs1541976):the genotype distribution and allele frequency of the two groups were statistically significant (P<0.05).There was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).The genotype distribution and allele frequency of the two groups were statistically significant (P<0.05).The genotype distribution of male and female patients in DEACMP group was statistically significant (P<0.05),but there was no significant difference in allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between male and female patients in ACMP group (P>0.05).LRP1B gene locus (rs10183908):there was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in the genotype distribution between male and female patients in DEACMP group (P>0.05).The difference was statistically significant (P<0.05).There was no significant difference in the genotype distribution and gene frequency between male and female patients in ACMP group (P>0.05).CDH17 gene locus (rs2513796):there was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between male and female patients in DEACMP group (P>0.05).There was no significant difference in genotype distribution and allele frequency between male and female patients (P>0.05).Conclusion LRP1B gene locus (rs1541976) gene polymorphism is associated with DEACMP.The risk of DEACMP in male ACMP patients is increased,and the risk of A/C genotype is increased,and CAC genotype is prone to DEACMP.LRP1B gene locus (rs10183908) gene polymorphism was not associated with DEACMP.LRP1B gene polymorphism may have genetic susceptibility to sex in the pathogenesis of DEACMP.
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