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Association analysis of HLA-B*13∶01 allele with peripheral white blood cells counts in patients with trichloroethylene-induced medicamentosa-like dermatitis
Pages: 888-891
Year: Issue:  7
Journal: Occupation and Health

Abstract: [Objective] To explore the association of HLA-B* 13∶01 allele with peripheral white blood cells counts in patients with trichloroethylene-induced medicamentosa-like dermatitis (TMD).[Methods]20 TMD patients admitted to the hospital from January 2014 to October 2016 were consecutively chosen as study subjects.The sequence-based typing method was used for detecting HLA-B*13∶01 allele in the DNA samples from peripheral blood of all study subjects.The difference of white blood cells counts indices including maximums of total white blood cell count,lymphocyte count,mononuclear cell count,neutrophil count,eosinophil and basophil counts was analyzed between HLA-B*13∶01 carriers and non-carriers.The correlation between the number of HLAB*13∶01 alleles and white blood cells counts indices was also analyzed.[Results]The proportions of HLA-B*13∶01 non-carriers,heterozygous and homozygous HLA-B*13∶01 carriers were 20.0%,70.0% and 10.0%,respectively.There was no statistical difference of white blood cells counts indices between HLA-B*13∶01 carriers and non-carriers.The number of HLA-B*13∶01 alleles showed no significant correlation with white blood cells counts indices.[Conclusion]The association of HLA-B*13∶01 allele with peripheral white blood cells counts is not found in the present study.Further studies with larger sample size are needed to validate the results.
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