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An epidemiological investigation on children with fluorosis in coal burning fluorosis area of Zhijin District in Guizhou Province
Pages: 916-919
Year: Issue:  7
Journal: Occupation and Health

Abstract: [Objective] To probe into the distribution of coal burning fluorosis which may also affect children in age and sexuality by launching an epidemiological investigation followed by serological examination,provide new thoughts to the pathogenesis of fluorosis.[Methods] Zhijin District in Guizhou Province where coal-burning fluorosis is widely prevalent was chosen as the objective field.By selecting a cluster sample of local children who were between 6-16 years old,the population distribution research was unfolded with the cross sectional research methods.Dental fluorosis test,X-ray examination and serological examination were carried out simultaneously.[Results] The prevalence rate of children with fluorosis in coal burning fluorosis area of Zhijin District was 7.55%.The difference in the prevalence rate was statistically significant among different age groups (P<0.05),while the prevalence rates in the groups of 10-<13 and 13-16 year-old was both higher than that in 6-<10 year-old age group (P<0.05).The contents of trace elements (Ca,Mg,Fe,Zn and Cu) in whole blood of children who suffered from skeletal fluorosis were lower than those of children in the control group,and the differences were statistically significant (P<0.05).Meanwhile,there was no statistically significant difference in serum phosphorus between two group (P>0.05).There were statistically significant differences in the contents of osteoprotegerin (OPG) and basic fibroblast growth factor (bFGF) between the skeletal fluorosis group and the control group (P<0.05).There were statistically significant differences in the contents of OPG and bFGF between the group of sclerotic type of skeletal fluorosis and the control group (P<0.05).[Conclusion] The total prevalence rate of fluorosis among children in coal burning fluorosis area of Zhijin District is high,and it increases with age.For the reason of physiological function of fluorine which is able to regulate bone metabolism and toxic to living cells,the contents of trace elements in whole blood from children who suffered from skeletal fluorosis decrease significantly.The contents of OPG and bFGF,which are biomarker of bone metabolism,respectively decrease and increase in theskeletal fluorosis group as compare with the control group,especially in the group of sclerotic type of skeletal fluorosis.
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