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Relationship between Serum FGF23 Level and Carotid Plaque Stability in Patients with Type 2 Diabetes Mellitus Combined with Carotid Artery Stenosis
Pages: 200-203
Year: Issue:  3
Journal: Neural Injury and Functional Reconstruction

Abstract: Objective:To investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis.Methods:Seventy-eight cases of patients with type 2 diabetes mellitus were enrolled,and were divided into without internal carotid artery stenosis (WICAS) group (n=47) and internal carotid artery stenosis (ICAS) group (n=31).The serum level of FGF23 and osteoprotegerin (OPG),the degree of carotid stenosis,carotid plaque stability and cardiovascular disease history were analyzed and compared between the 2 groups.Whether serum level of FGF23 is associated with intemal carotid artery stenosis and carotid plaque stability,and whether it correlates with inlammatory cytokines High-Sensitivity C-reactive protein (Hs-CRP) and interleukin-6 (IL-6) were analyzed.Results:The serum level of FGF23 in ICAS group [(67.7±7.8)pg/mL] was significant higher than that in WICAS group [(43.8±6.5)pg/mL] (P<0.05).The serum level of FGF23 was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis (P<0.001).Conclusion:The serum level of FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.
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