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The Clinical Efficacy of Hypertonic Saline in Reducing Intracranial Pressure in Patients with Severe Traumatic Brain Injury
Pages: 215-217
Year: Issue:  3
Journal: Neural Injury and Functional Reconstruction

Abstract: Objective:To evaluate the difference of clinical efficacy between hypertonic saline and mannitol in reducing intracranial pressure (ICP) in patients with severe traumatic brain injury.Methods:One hundred and thirty-two patients with severe traumatic brain injury were randomly divided into hypertonic saline group (n=65) and mannitol group (n=67).In addition to regular therapy for severe traumatic brain injury,the cases in the hypertonic saline group were treated with 3% hypertonic saline 5.4 mL/kg and those in the mannitol group were treated with 20% mannitol 5.0 ml/kg respectively.Indexes including onset time,maximum descend range of ICP,cumulative ICP burden (CICPB),average ICP load time,time pressure involved (PTD),ICU stay duration and Glasgow outcome scale (GOS) were evaluated after the treatment.Results:There was no significant differences in onset time,maximum descend range of ICP between the 2 groups (P>0.05).PTD,CICPB and ICP load time in the hypertonic saline group were less than those in the mannitol group (P<0.05).There was no siginificant differences in ICU stay,GOS score and clinical prognosis between the two groups (P>0.05).Multiple regression analysis with GOS score as a dependent variable showed that PTD,CICPB and ICP load time were negatively correlated with GOS (P<0.05),and onset time,maximum ICP decrease had no relation with GOS (P>0.05).Conclusion:Hypertonic saline was better than mannitol in reducing ICP in patients with severe traumatic brain injury.However,the method could not significantly improve clinical outcomes of patients.
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