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Analysis of Cerebral Metabolisms by Magnetic Resonance Spectroscopy in Patients with Post-stroke Depression
Pages: 228-230,237
Year: Issue:  3
Journal: Neural Injury and Functional Reconstruction

Abstract: Objective:To investigate the characteristics of cerebral metabolism in patients with post-stroke depression (PSD) using magnetic resonance spectroscopy (MRS).Methods:1H-MRS brain scans were taken on 10 acute stroke patients with depression (PSD group) and 10 acute stroke patients without depression (no-PSD group).The neurochemical abnormalities including the levels of N-acetyl aspartate (NAA),Choline (Cho),Myo-inositol (mI) and Creatine (Cr) were measured and the ratios of NAA/Cr,Cho/Cr,mI/Cr were calculated in both the temporal lobe,thalamus and the lesion site.Results:The patients with PSD had lower NAA and NAA/Cr ratios,higher Cho and Cho/Cr ratios in the bilateral temporal lobes as well as lower NAA,higher mI/Cr in the left thalamus,compared to those in the no-PSD group (P<0.05).Conclusion:The characteristics of cerebral metabolism in PSD can be determined by MRS,which may be helpful for early diagnosis and understanding the pathogenesis of PSD.
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