The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
The Expression and Clinical Significance of miR-132 in Glioma
Pages: 221-224
Year: Issue:  3
Journal: Neural Injury and Functional Reconstruction

Abstract: Objective:To investigate the expression and clinical significance of microRNA (miR-132) in patients with glioma.Methods:One hundred thirty-five cases with glioma (glioma group) and 53 cases of normal brain tissues (control group) were collected.Real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the miR-132 expression in 2 groups.The clinic pathological characteristics ofmiR-132 expression were further analyzed.A receiver operating characteristic (ROC) curve was constructed to determine the diagnostic value of miR-132.Results:miR-132 expression was significantly up-regulated in the glioma group compared with that in the normal group (P<0.05).There was significant differences between KPS score,extent of resection and WHO grade in terms of miR-132 expression (P<0.05).The area under the ROC curve was 0.856 (P<0.001),the sensitivity was 52.7%,the specificity was 86.6% and the index of Youden was 0.465.The overall survival time and progression free survival in miR-132 high expression and low expression sub-groups were statistically significant (P<0.01).Conclusion:miR-132 may be involved in carcinogenesis of glioma,which may be a new biomarker for diagnosis and treatment.
Related Articles
No related articles found