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Lineage switch at relapse of acute promyelocytic leukemia: report of one case and review of literature
Pages: 359-361
Year: Issue:  6
Journal: Journal of Leukemia & Lymphoma

Abstract: 目的 观察成年人急性早幼粒细胞白血病(APL)治疗后转变为急性单核细胞白血病(M5)的发生过程.方法 对1例APL患者诊断、缓解和复发的整个过程应用细胞形态学、免疫组织化学、细胞遗传学和分子遗传学方法进行监测.结果 该患者经骨髓细胞形态学、染色体以及融合基因检查确诊为APL,缓解期间PML-RARα融合基因转阴;完全缓解4个月后复发,此时染色体未见异常,但细胞形态和分子遗传学检查提示转变为M5,转型后再次诱导治疗无效出院.结论 APL治疗后转变为M5的病例临床较为罕见,转型后治疗效果不佳.
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