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China/Asia On Demand
Journal Articles
Epidemiological characteristic analysis of the carbapenem-resistant Enterobacteriaceae in a hospital from 2008 to 2016
Pages: 408-412
Year: Issue:  5
Journal: Chinese Journal of Antibiotics

Abstract: Objective To provide the basis for the clinical control and treatment of such infections,we investigate the distribution and antibiotic resistance of carbapenem resistant Enterobacteriaceae(CRE) in clinical isolates from a hospital in Beijing during 2008-2016.Methods The drug sensitivity test was carried out with the method of disc diffusion (KB) or VITEK 2 COMPACT.Susceptibility tests and the result analysis according to the CLSI 2015-M100 standard.Results A total of 703 clinical isolates of CRE were isolated in 2008-2016,including 537 strains of Klebsiella pneumoniae,59 strains of E.coli and 47 strains of Enterobacter spp.The detection rate of CRE was 3.1%,which was increasing year by year.The source and the distribution of the patients were the respiratory tract specimens (44.2%) and the ICU wards (45.2%).The highest isolation rate was from the respiratory tract (5%) and respiratory care unit (26.8%).Drug sensitivity test results showed that,the resistance rates of CRE to amikacin,cotrimoxazole and gentamicin were 50.3%,53.1% and 69.1%,respectively.The resistant rates to other antibiotics were almost more than 80%.The resistance of carbapenem resistant Klebsiella pneumoniae was more serious than the average,but the resisitance of carbapenem resistant Escherichia coli and Enterobacter spp.were lower than the average level.Conclusion The strain of CRE was increasing year by year,and it was highly resistant to most of the commonly used antibiotics.Therefore we should take effective measures to control the infections to prevent the spread of such strains.
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