Pages: 389-395
Year: 2017 Issue:  5
Journal: Chinese Journal of Antibiotics
Abstract: Objective To study the formulation,the preparation technology and the in vitro dissolution behavior of tedizolid phosphate tablets.Methods According to the formulation and in vitro dissolution behavior of "SIBEXTRO" on foreign markets,experiments were carried out on its binders,disintegrating agents,diluents and coating weights.A reasonable formulation and the preparation technology was screened and large scale production was taken out.Results The formulation was ultimately determined including 200mg oftedizolid phosphate,120mg of mannitol,50mg of microcrystalline cellulose,6mg povidone,12mg(inside) of crospovidone,8mg(outside) of crospovidone,4mg of magnesium stearate,12mg of pellicle coating pre-mixing agent,and purified water as a binder.Conclusion The formulation and the preparation technology determined is stable and suitable for the amplification production.The in vitro dissolution behavior of the corresponding tablets is similar to that of the commercial products.