Pages: 401-407
Year: 2017 Issue:  5
Journal: Chinese Journal of Antibiotics
Abstract: Objective To explore the antimicrobial susceptibility of Burkholderia pseudomallei isolates from Hainan patients.Methods A total of 101 strains were collected from Hainan during January 2008 and March 2013.Susceptibility tests were done by the E-test method.Results The most common type of infections in this study was sepsis,accounting for 59.4％(60 cases),followed by pneumonia,accounting for 21.8％ (22 cases).The wound and skin soft tissue infection were 16.8％(17 cases),and urinary tract infections were 2.0％(2 cases).The total mortality of melioidosis was 17.8％(18/101) and 72.2％ of the deaths were suffering from sepsis.In vitro drug susceptibility test results showed that all isolates had good sensitivity to meropenem,imipenem,levofloxacin,ceftazidime and amoxicillin/clavulanic acid,the sensitivity rates for them were 100％,100％,94.4％,92.1％ and 90.1％,respectively.The sensitivity rates of tetracycline and cotrimoxazole were 85.1％ and 84.2％.Conclusions Our research and other reports have confirmed that Burkholderia pseudomallei had a good sensitivity to antibiotics which were international recommended to use in the treatment of this diseases.Particularly,imipenem and meropenem can be used as the preferred drug for treatment.