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China/Asia On Demand
Journal Articles
Antimicrobial susceptibility of Burkholderia pseudomallei isolated from Hainan patients
Pages: 401-407
Year: Issue:  5
Journal: Chinese Journal of Antibiotics

Abstract: Objective To explore the antimicrobial susceptibility of Burkholderia pseudomallei isolates from Hainan patients.Methods A total of 101 strains were collected from Hainan during January 2008 and March 2013.Susceptibility tests were done by the E-test method.Results The most common type of infections in this study was sepsis,accounting for 59.4%(60 cases),followed by pneumonia,accounting for 21.8% (22 cases).The wound and skin soft tissue infection were 16.8%(17 cases),and urinary tract infections were 2.0%(2 cases).The total mortality of melioidosis was 17.8%(18/101) and 72.2% of the deaths were suffering from sepsis.In vitro drug susceptibility test results showed that all isolates had good sensitivity to meropenem,imipenem,levofloxacin,ceftazidime and amoxicillin/clavulanic acid,the sensitivity rates for them were 100%,100%,94.4%,92.1% and 90.1%,respectively.The sensitivity rates of tetracycline and cotrimoxazole were 85.1% and 84.2%.Conclusions Our research and other reports have confirmed that Burkholderia pseudomallei had a good sensitivity to antibiotics which were international recommended to use in the treatment of this diseases.Particularly,imipenem and meropenem can be used as the preferred drug for treatment.
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