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bing wu suan na xiang guan xing gao xue an nao bing 1 li bao dao bing wen xian fu xi
Author(s): 
Pages: 557-559
Year: Issue:  6
Journal: Journal of International Neurology and Neurosurgery

Keyword: 
Abstract: 丙戊酸钠相关性高血氨脑病(valproate-induced hyperammonemic encephalopathy,VHE)是颅脑手术后一种严重的、罕见的中枢神经系统副反应.主要的临床表现为各种意识障碍如:嗜睡、谵妄、波动性意识障碍甚至一过性昏迷、扑翼样震颤、瞳孔散大、木僵、癫痫发作、肢体功能障碍等等[1].以上症状是可逆的,确诊停药后,多可自行缓解.引起血丙戊酸钠浓度相对升高的因素很多,可能与患者的体重、年龄、药物的相互作用以及患者对药物耐受的个体差异等有关.因此,实时监测丙戊酸钠血药浓度并结合患者自身特点个体化用药能更好地减少不良反应的发生.
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